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Learning target / Competences
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The students obtain an integral and comprehensive understanding of biotechnical processes and their technical realization. By means of small groups working on various partial aspects of a common project their capacity for teamwork is promoted. For example in the laboratory the students, within their group, are encouraged to work out their individual experimental programme. In view of carrying scientific work or indutrial research and development they learn to accept that not all ideas and concepts can be realized within the framework of given means and time, or if realizable that in retrospect it may not have been useful.
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Lectures
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Dimensioning Biotechnical Processes
| Type |
Lecture |
| Nr. |
M+V933 |
| Hours per week |
4.0 |
| Content |
The lecture is composed of two parts: Biological Aspects, and Process and Mechanical Fermenter Design.
(A) Biological Aspects (Zell)
- Biological aspects of fermenter design
- Modelling of microorganism growth mechanisms
(B) Process and Mechanical Fermenter Design (Schneider)
- Continuity laws for mass, energy and impulse
- Flow patterns in stirred tanks, types of impellers
- Scaling-up of mixing processes
- Principles of flow simulation
- Mechanical design of fermenters
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| Literature |
- Dunn, I.J.; Heinzle, E.; Ingham, J.; Prenosil, J.E.: Biological Reaction Engineering; Wiley-VCH, 2003
- Chmiel, H.: Bioprozesstechnik; Elsevier Spektrum Akademischer Verlag, 2006
- Subramanian, G.: Bioseparation and Bioprocessing; Wiley VCH, 2nd edition 2007
- Handbook of Mixing / Handbuch der Rührtechnik; EKATO Rühr- und Mischtechnik GmbH, 1st ed. 1991 (in English), 2nd ed. 2000 (in German)
- Ullmann’s Biotechnology and Biochemical Engineering; Wiley VCH, 2007
- Layout of pressure vessels - cylinder and spherical shells under internal overpressure; AD work sheets B0 and B1 (in German); Beuth Verlag
- Zierep, J.: Ähnlichkeitsgesetze und Modellregeln; Braun Verlag, Berlin 1991
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Laboratory Biotechnical Processes
| Type |
Lab |
| Nr. |
M+V934 |
| Hours per week |
4.0 |
| Content |
Two projects are currently offered:
- Fermentation: The students produce independently under guidance a product to be selected (for example Xanthan-gum or baking yeast) in a fermenter. This includes timing, preparation, and performing the fermentation, as well as processing and examination of the product.
- Scale-up of Mixing Processes: In open mixing vessels the conditions in stirred fermenters are simulated by means of model liquids. Possible aspects:
- Development of a model liquid simulating a fermentation broth
- Selection of a suitable type of stirrer, determination of required speeds and power inputs
- Observation of the flow mechanics in stirred tanks
- Rheology: correlation between viscosity curves of liquids and viscosities effective in stirred tanks
- Measurement of the effect of viscosity on mixing time and mass transfer in model liquids
- Determination of the shear sensitivity of micro-organisms and liquids containing organic components
- Development of scale-up rules for selected mixing tasks from experiments in two different scales (3 and 30 ltr volume)
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| Literature |
- Zell, C.; Wilke, A.: Technical School Fermentation; laboratory instructions, HSO 2009ff
- Schneider, T.: Technical School Scale-up of Mixing Processes; laboratory instructions, HSO 2016
- Dunn, I.J.; Heinzle, E.; Ingham, J.; Prenosil, J.E.: Biological Reaction Engineering; Wiley-VCH, 2003
- Handbook of Mixing / Handbuch der Rührtechnik; EKATO Rühr- und Mischtechnik GmbH, 1991 / 2000+2012
- Stieß, M.: Mechanische Verfahrenstechnik, volumes 1 and 2; Springer, 2002
- Maßstabsvergrößerung / Scale-up, Praktikum Bioreaktionstechnik; TU Berlin
- Forschner, P.; Krebs, R.; Schneider, T. et al: Scale-up Procedures for Power Calculation in Mixing of non-Newtonian Liquids; AIChE Symposium Series No. 286, volume 88 (1992), pp. 38-43
- Nienow, A.: Scale-up, scale-down of stirred bioreactors; Bioreactor Eng. Course; Otocec 1987
- C.Buurman et al: Scaling-Up Rules for Solids Suspension in Stirred Vessels; Proc. 5th European Conf. Mixing, 1985, pp.15ff, and Chem. Eng. Sci 41/11 (1986), pp. 2865ff
- Rieger, F.; Novak, V.: Power Consumption Scale-up in Agitating Non-Newtonian Fluids; Chem. Eng. Sci. 29 (1974), pp. 2229ff
- Nishikawa, M. et al: Scale-up of l/l phase mixing vessel; J. Chem. Eng. Japan 20/5 (1987), pp. 454ff
- Mersmann, A. et al: Auslegung und Maßstabsvergrößerung von Rührapparaten; Chem.-Ing.-Tech. 47/23 (1975), pp. 953ff
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